Cholesterol-free and cholesterol-bound Hedgehog

Cholesterol modification of Hedgehog family proteins.

(Hh) gene family encodes a group of secreted signaling molecules that are essential for growth and patterning of many different body parts of vertebrate and invertebrate embryos (1). Depending on the context, Hh signals can promote cell proliferation, prevent apoptosis, or induce specific cell fates. Hh family members can exert their effects not only on cells neighboring the source of the signa...

Hedgehog signalling: How cholesterol modulates the signal

Developing embryos are replete with a variety of potent signalling proteins, the activities of which must be precisely regulated for development to follow its proper course. In principle, such signals may take two distinct forms. Proteins tethered to the membrane of a signalling cell — for instance via a transmembrane domain or lipid modification — might be expected to act as short-range switch...

Serum Cholesterol Level and its Association with their Fats and Cholesterol Intake.

ABSTRACT Cholesterol and particularly LDL-c is one of the most important risk factors of cordiovascular disease. The most important environmental factor that influence this anomaly is nutritional status. The aim of this Cross-Sectional study was determination of the level of serum cholesterol and its association with fats and cholesterol intake. we selected 628 men and women aged 35-65 years o...

Greased hedgehogs: new links between hedgehog signaling and cholesterol metabolism.

The close link between signaling by the developmental regulators of the Hedgehog family and cholesterol biochemistry has been known for some time. The morphogen is covalently attached to cholesterol in a peculiar autocatalytic reaction and embryonal disruption of cholesterol synthesis leads to malformations that mimic Hh signaling defects. Recently, it was furthermore shown that secreted Hh cou...

Stoichiometry of interaction of the polyene antibiotic, filipin, with free and liposomal-bound cholesterol.